The film, based on a true story, takes place in 1962. Italian-American Tony, nicknamed "Chatterbox," works as a bouncer in one of the upscale nightclubs in the Bronx. When the establishment closes for repairs, Tony decides to find a temporary job, and soon he has a great offer. Don Shirley, a famous African-American pianist, is going on a tour of the southern states, and he needs a good driver and a man who can solve any problem on the road, all in one person. After negotiating the terms and coming to an agreement, the talented musician and the Bronx bouncer hit the road, taking with them the Green Book, a special guidebook that describes all the safe places for African-Americans.